peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) main mediator for endurance adaptations: •Mitochondrial biogenesis •Angiogenesis •Fat oxidation ·PGC-1α induces all the muscular adaptations to endurance exercise
Training should look to maximise PGC-1α levels(Baar, 2014)
The Science behind Running 